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Published Work from Wang Lab

https://www.ncbi.nlm.nih.gov/myncbi/jing.wang.4/bibliography/public/

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Science Student

Earlier work from Dr. JH Wang

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  1. Chen Z, Ma D, Wang J, Zhang Y, Wang L, Yuan Y, Liu H (1998). Secretory expression of the fusion protein composed of human IL-2 and PreS antigen of Hepatitis B virus in mammalian cells. Chinese Science Bulletin 43(9), 781-784. https://link.springer.com/article/10.1007/BF02898960

  2. Wu Q, Wang Y, Wang J, Hedgeman E.O, Browning J, and Fu Y-X (1999). The requirement of membrane lymphotoxin for the presence of dendritic cells in lymphoid tissues.  Journal of Experimental Medicine, 190, 629-38. PMID: 10477548.

  3. Wang Y, Huang G, Wang J, Molina H, Chaplin D.D, and Fu Y-X (2000). Antigen persistence is required for somatic mutation and affinity maturation of immunologloblin.  European Journal of Immunology, 30, 2226-2234. PMID: 10940914.

  4. Wu Q, Sun Y, Wang J, Lin X, Wang Y, Pegg L, Futterer A, Pfeffer K, and Fu Y-X (2001). Signal via lymphotoxin-beta R on bone marrow stromal cells is required for an early checkpoint of NK cell development. Journal of Immunology 166, 1684-1689. PMID: 11160211.

  5. Wang Y, Wang J, Sun Y, Wu Q, Fu Y-X (2001). Complementary effects of TNF and lymphotoxin on the formation of germinal center and follicular dendritic cells.  Journal of Immunology, 166, 330-347. PMID: 11123309.

  6. Wang J, Chun T, Lo J C, Wu Q, Wang Y, Foster A, Roca K, Chen M, Tamada T, Chen L, Wang C-R, and Fu Y-X (2001). The critical role of LIGHT, a TNF family member, in T cell development. Journal of Immunology 167, 5099-5105. PMID: 11673520.

  7. Wang J, Lo J C, Foster A, Yu P, Chen H M, Wang Y, Tamada K, Chen L, and Fu Y-X (2001). The regulation of T cell homeostasis and autoimmunity by T cell derived LIGHT. Journal of Clinical Investigation, 108, 1771-1780.  (Commentary published on Journal of Clinical Investigation). PMID: 11748260.

  8. Wang J, Foster A, Chin R, Yu P, Wang Y, Pfeffer K and Fu Y-X (2002). The complementation of lymphotoxin deficiency with LIGHT, a newly discovered TNF family member, for the restoration of secondary lymphoid structure and function. European Journal of Immunology, 32, 1969-79. PMID: 12115617.

  9. Wang J and Fu Y-X. LIGHT-mediated thymocyte selection is dependent on the interaction between TCR and MHC/peptide (2003). Journal of Immunology, 170, 3986-3993. PMID: 12682226.

  10. Yu P, Lee Y, Liu W, Chin R K, Wang J, Wang Y, Schietinger A, Schreiber H, and Fu Y-X (2004). Priming of naive T cells inside tumors leads to eradication of established tumors. Nature Immunology, 5, 141-149.  (News and Views published on Nature Immunology). PMID: 14704792.

  11. Wang J, Anders R A, Wu Q, Peng D, Cho J H, Sun Y, Karaliukas R, Kang H S, Turner J R, Fu Y-X (2004). Dysregulated LIGHT expression on T Cells mediates intestinal inflammation and contributes to IgA nephropathy. Journal of Clinical Investigation, 113, 826-835. PMID: 15067315. 

  12. Zarrin AA, Tian M, Wang J, Borjeson T, and Alt FW (2005). Influence of Switch Region Length on Immunoglobulin Class Switch Recombination. Proc. Natl. Acad. Sci. USA, 102(7), 2466-2470. PMID: 15684074.

  13. Wang Y, Subudhi SK, Anders RA, Lo J, Sun Y, Blink S, Wang Y, Wang J, Liu X, Mink K, Degrandi D, Pfeffer K, and Fu Y-X (2005). The role of herpesvirus entry mediator as a negative regulator of T cell-mediated responses. Journal of Clinical Investigation, 115, 711-717. PMID: 15696194.

  14. Wang J, Anders R A, Wang Y, Turner J R, Abraham C, Pfeffer K and Fu Y-X (2005).  The Critical Role of LIGHT in Promoting Intestinal Inflammation and Crohn’s Disease. Journal of Immunology, 174, 8173-8182. PMID: 15944326.

  15. Anders RA, Subudhi SK, Wang J, Pfeffer K, and Fu Y-X (2005). Contribution of the lymphotoxin beta receptor to liver regeneration. Journal of Immunology, 175, 1295–1300. PMID: 16002734.

  16. Wang Y-G, Kim KD, Wang J, Yu P and Fu Y-X (2005). Stimulating Lymphotoxin beta Receptor on the Dendritic Cells is Critical for Their Homeostasis and Expansion. Journal of Immunology, 175, 6997–7002. PMID: 16272360.

  17. Lee Y, Chin RK, Christiansen P, Sun Y, Tumanov AV, Wang J, Chervonsky A, and Fu Y-X (2006). Recruitment and Activation of Naive T Cells in the Islets by Lymphotoxin b Receptor-Dependent Tertiary Lymphoid Structure. Immunity, 25, 1-12. PMID: 16934497.

  18. Wang JH, Alt FW, Gostissa M, Datta A, Murphy M, Alimzhanov MB, Coakley KM, Rajewsky K, Manis JP, Yan CT (2008).  Oncogenic transformation in the absence of Xrcc4 targets peripheral B cells that have undergone editing and switching. Journal of Experimental Medicine, 205(13), 3079-90.  (Commentary published on Cell). PMID: 19064702.

  19. Wang JH, Gostissa M, Yan CT, Goff P, Hickernell T, Hansen E, Difilippantonio S, Wesemann DR, Zarrin AA, Rajewsky K, Nussenzweig A, Alt FW (2009). Mechanisms Promoting Translocations in Editing and Switching Peripheral B Cells. Nature, 460(7252), 231-6.  (News and Views published on Nature). PMID: 19587764.

  20. Ruccia F, Notarangeloa LD, Fazeli A, Patrizi L, Hickernell T, Paganini T, Coakley K, Cheng HL, Feldman L, Wang JH, Balter B, Zha S, Detre C, Walter JE, Keszei M, Poliani PL, Giliani S, Terhorst C, Alt FW, Yan CT (2010).  Homozygous DNA Ligase IV R278H mutation in mice leads to leaky SCID and represents a model for human LIG4 syndrome. Proc. Natl. Acad. Sci. USA, 107(7):3024-9. PMID: 20133615.

  21. Boboila C, Yan C, Wesemann DR, Jankovic M, Wang JH, Manis J, Nussenzweig A, Nussenzweig M, Alt FW (2010). Alternative End-joining Catalyzes Class Switch Recombination in the Absence of Both Ku70 and DNA Ligase 4. Journal of Experimental Medicine, 207(2):417-27. PMID: 20142431.

  22. Boboila C, Jankovici M, Yan CT, Wang JH, Wesemann DR, Zhang T, Fazeli A, Feldmane L, Nussenzweig A, Nussenzweig M, Alt FW (2010).  Alternative End-joining Catalyzes Robust IgH Locus Deletions and Translocations in the Combined Absence of Ligase 4 and Ku70. Proc. Natl. Acad. Sci. USA, 107(7):3034-9. PMID: 20133803.

Plant Biologist

Original Papers from Dr. JH Wang's lab

  1. Chen Z, Viboolsittiseri SS, O’Connor BP, Wang JH (2012). Target DNA Sequence Directly Regulates the Frequency of AID-Dependent Mutations. Journal of Immunology, 189(8):3970-82. PMID: 22962683 (Featured article in the issue).

  2. Chen Z, Yan CT, Dou Y, Viboolsittiseri SS, Wang JH (2013). The Role of a Newly Identified SET Domain-Containing Protein, SETD3, in Oncogenesis. Haematologica, 98(5):739-43. PMID: 23065515.

  3. Chen Z, Ranganath S, Viboolsittiseri SS, Eder MD, Chen X, Elos MT, Yuan S, Hansen E, Wang JH (2014). AID-Initiated DNA Lesions Are Differentially Processed in Distinct B cell Populations. Journal of Immunology, 2014 Dec 1;193(11):5545-56. PMID: 25339658.

  4. Yeap LS, Hwang J K, Du Z, Meyers RM, Meng FL, Jakubauskait A, Liu M, Mani V, Neuberg D, Kepler TB, Wang JH*, and Alt FW* (2015). Sequence-Intrinsic Mechanisms that Target AID Mutational Outcomes on Antibody Genes. Cell 163: 1124-1137. *co-senior authorship. (Leading Edge Previews published on Cell). PMID: 26582132.

  5. Chen Z*,§, Getahun A*, Chen X, Dollin Y, Cambier JC, Wang JH§ (2015). Imbalanced PTEN and Phosphoinositide 3-kinase signaling impairs class switch recombination. Journal of Immunology 195: 5461-5471. *co-first author; §co-correspondence author. (Featured article in the issue). PMID: 26500350.

  6. Chen Z, Eder MD, Elos MT, Viboolsittiseri SS, Chen X, Wang JH (2016). Interplay between Target Sequences and Repair Pathways Determines Distinct Outcomes of AID-Initiated Lesions. Journal of Immunology, 2016; 196(5):2335-47. PMID: 26810227.

  7. Chen Z, Elos MT, Viboolsittiseri SS, Gowan K, Leach SM, Rice M, Eder MD, Jones K, Wang JH (2016). Combined deletion of Xrcc4 and Trp53 in mouse germinal center B cells leads to novel B cell lymphomas with clonal heterogeneity. Journal of Hematology & Oncology. 2016 Jan 7;9(1):2. PMID: 26740101.

  8. Chen Z, Gowan K, Leach SM, Viboolsittiseri SS, Mishra AK, Kadoishi T, Diener K, Gao B, Jones K, Wang JH (2016). Unexpected Effects of Different Genetic Backgrounds on Identification of Genomic Rearrangements via Whole-genome Next Generation Sequencing (2016). BMC Genomics, 17(1):823. PMID: 27769169.

  9. Mishra AK, Kadoishi T, Wang X, Driver E, Chen Z, Wang XJ, Wang JH. Squamous Cell Carcinomas Escape Immune Surveillance via Inducing Chronic Activation and Exhaustion of CD8+ T Cells co-expressing PD-1 and LAG-3 Inhibitory Receptors. Oncotarget, 2016; 7(49):81341-81356. PMID: 27835902.

  10. Wang X, Chen Z, Mishra AK, Silva A, Ren W, Pan Z, Wang JH (2018). Chemotherapy-induced differential cell cycle arrest in B-cell lymphomas affects their sensitivity to Wee1 inhibition. Haematologica. Mar;103(3):466-476. PMID: 29217775.

  11. Woolaver RA, Wang X, Dollin Y, Xie P, Wang JH*, Chen Z*. TRAF2 Deficiency in B Cells Impairs CD40-Induced Isotype Switching That Can Be Rescued by Restoring NF-κB1 Activation. Journal of Immunology, 2018 Dec 1;201(11):3421-343. *co-senior authorship. (Featured article in the issue). PMID: 30341187.

  12. Wang X, Waschke BC, Woolaver RA, Chen Z, Zhang G, Piscopio AD, Liu X, Wang JH. Histone-deacetylase inhibition sensitizes PD1 blockade–resistant B-cell lymphomas. Cancer Immunology Research. 2019 Aug;7(8):1318-1331. PMID: 31235619.

  13. Wang X, Waschke BC, Woolaver RA, Chen SMY, Chen Z, Wang JH. MHC class I-independent activation of virtual memory CD8 T cells induced by chemotherapeutic agent-treated cancer cells. Cellular & Molecular Immunology. 2020 May 19. doi: 10.1038/s41423-020-0463-2. Online ahead of print. PMID: 32427883. (Commentary published on CMI).

  14. Chen Z*, Krinsky A, Woolaver RA, Wang X, Chen SMY, Popolizio V, Xie P, Wang JH*. TRAF3 Acts as a Checkpoint of B Cell Receptor Signaling to Control Antibody Class Switch Recombination and Anergy. Journal of Immunology. 2020 Aug 1; 205(3):830-841. PMID: 32591397. *co-senior authorship.

  15. Chen SMY, Li B, Nicklawsky AG, Krinsky A, Brunetti T, Woolaver RA, Wang X, Chen Z, Young CD, Gao D, Wang XJ, Wang JH. Deletion of p53 and Hyper-Activation of PIK3CA in Keratin-15+ Stem Cells Lead to the Development of Spontaneous Squamous Cell Carcinoma. International Journal of Molecular Sciences. 2020, 21(18), 6585; https://doi.org/10.3390/ijms21186585. PMID: 32916850

  16. Woolaver RA, Wang X, Krinsky AL, Waschke BC, Chen SMY, Popolizio V, Nicklawsky AG, Gao D, Chen Z, Jimeno A, Wang XJ, Wang JH. Differences in TCR repertoire and T cell activation underlie the divergent outcomes of anti-tumor immune responses in tumor-eradicating versus tumor-progressing hosts.  Journal for ImmunoTherapy of Cancer (JITC). 2021 Jan;9(1):e001615. doi: 10.1136/jitc-2020-001615. PMID: 33414263

Scientist Pipetting

Collaborative work and Review Articles

  1. Jeevan-Raj BP, Robert I, Heyer V, Page A, Wang JH, Cammas F, Alt FW, Losson R and Reina-San-Martin B (2011).  Epigenetic tethering of AID to the donor switch region during immunoglobulin class switch recombination. Journal of Experimental Medicine, 208(8):1649-60. PMID: 21746811.

  2. ​Boboila C, Oksenych V, Gostissa M, Wang JH, Zha S, Zhang Y, Chai H, Lee CS, Jankovic M, Saez LM, Nussenzweig MC, McKinnon PJ, Alt FW, Schwer B (2012). Robust chromosomal DNA repair via alternative end-joining in the absence of X-ray repair cross-complementing protein 1 (XRCC1). Proc. Natl. Acad. Sci. USA, 109(7):2473-8. PMID: 22308491.

  3. Hosomi S, Chen Z*, Baker K, Chen L, Huang YH, Olszak T, Zeissig S, Wang JH, Mandelboim O, Beauchemin N, Lanier LL, Blumberg RS (2013). CEACAM1 on activated NK cells inhibits NKG2D-mediated cytolytic function and signaling. European Journal of Immunology, 2013 May 22. PMID: 23696226. *Equal contribution to the work.

  4. Lu Y, Wu Y, Feng X, Shen R, Wang JH, Fallahi M, Li W, Yang C, Hankey W, Li MO, Cleveland JL and Zou X (2014). Cdk4 deficiency augments Myc-driven lymphomagenesis via a Foxo1-Rag1/Rag2 pathway that provokes genomic instability. Journal of Clinical Investigation, 124(4):1672-84. PMID: 24614102.

  5. Wu F, Bian L, Nolan K, Wang JH, Jimeno A, Zhou H, Young CD, Wang XJ. Macrophages promote growth of squamous cancer independent of T cells. Journal of Dental Research, 2019 Jul;98(8):896-903. PMID: 31189369.

  6. Morton JJ, Alzofon N, Keysar SB, Chimed TS, Reisinger J, Perrenoud L, Le PN, Nieto C, Gomez K, Miller B, Yeager R, Gao D, Tan AC, Somerset H, Medina T, Wang XJ, Wang JH, Robinson W, Roop DR, Gonzalez R, Jimeno A. Studying immunotherapy resistance in a melanoma autologous humanized mouse xenograft. Molecular Cancer Research. 2020 Oct 21. doi: 10.1158/1541-7786.MCR-20-0686. Online ahead of print. PMID: 33087417

  7. Wang JH. Mechanisms and impacts of chromosomal translocations in cancers. Frontiers of Medicine, 2012 Sep;6(3):263-74. PMID: 22865120.

  8. Chen Z and Wang JH. Generation and Repair of AID-initiated DNA Lesions in B Lymphocytes. Frontiers of Medicine. 2014 Jun;8(2):201-16. doi: 10.1007/s11684-014-0324-4. PMID: 24748462.

  9. Hernandez AL, Young CD, Wang JH, Wang XJ. Lessons learned from SMAD4 loss in squamous cell carcinomas. Molecular Carcinogenesis. 2019 Sep;58(9):1648-1655. doi: 10.1002/mc.23049. Epub 2019 May 29. PMID: 31140647.

  10. Wang X, Waschke BC, Woolaver RA, Chen SMY, Chen Z, Wang JH.  HDAC inhibitors overcome immunotherapy resistance in B-cell lymphoma. Protein & Cell. 2020 Jul;11(7):472-482. doi: 10.1007/s13238-020-00694-x. PMID: 32162275.

  11. Chen SMY, Krinsky AL, Woolaver RA, Wang X, Chen Z, Wang JH. Tumor Immune Microenvironment in Head and Neck Cancers. Molecular Carcinogenesis. 2020 Jul;59(7):766-774. doi: 10.1002/mc.23162. Epub 2020 Feb 3. PMID: 32017286.

  12. Wang JH. Why the Outcome of Anti-Tumor Immune Responses is Heterogeneous: A Novel Idea in the Context of Immunological Heterogeneity in Cancers. BioEssays. 2020 Oct;42(10):e2000024. doi: 10.1002/bies.202000024. Epub 2020 Aug 7. PMID: 32767371.

  13. Chin R, Wang J and Fu Y-X. Lymphoid microenvironment in the gut for immunoglobulin A and inflammation. Immunological Review, 2003 Oct;195:190-201. PMID: 12969319.

  14. Wang J and Fu Y-X.  The role of LIGHT in T cell-mediated immunity. Immunologic Research, 2004;30(2):201-14. doi: 10.1385/IR:30:2:201. PMID: 15477661.

  15. Wang J and Fu Y-X.  TNF family members and inflammatory bowel disease. Invited Review. Immunological Review, 2005 Apr;204:144-55. PMID: 15790356.

  16. Chaudhuri J, Basu U, Zarrin A, Yan C, Franco S, Perlot T, Vuong B, Wang J, Phan RT, Datta A, Manis J and Alt FW.  Evolution of the Immunoglobulin Heavy Chain Class Switch Recombination Mechanism. Advances in Immunology, 2007;94:157-214. doi: 10.1016/S0065-2776(06)94006-1. PMID: 17560275.

  17. Wang JH. The role of activation induced deaminase in antibody diversification and genomic instability. Immunologic Research, 2013 Mar;55(1-3):287-97. doi: 10.1007/s12026-012-8369-4. PMID: 22956489.

  18. Chen Z and Wang JH. Impact of Chromosomal Translocation and Genomic Instability on Personalized Medicine. Personalized Medicine, 2013 Mar;10(2):111-114. doi: 10.2217/pme.12.123. PMID: 29758842.

  19. Chen Z and Wang JH. Signaling control of antibody isotype switching. Advances in Immunology, 2019;141:105-164. PMID: 30904131.

Publications: Publications
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